Genetic determinants of statin intolerance
نویسندگان
چکیده
منابع مشابه
Insights Into Statin Intolerance
Stephen Kopecky, MD, FACC, FACP; Seth Baum, MD, FACC, FACPM, FAHA, FNLA; JoAnne M. Foody, MD, FACC, FAHA; Michael Koren, MD, FACC; James McKenney, PharmD, FNLA; Laurence Sperling, MD, FACC, FAHA, FACP; Nathan D. Wong, PhD, MPH, FACC, FAHA; Statin Intolerance Roundtable Participants Division of Cardiovascular Diseases (Kopecky), Mayo Clinic, Rochester, Minnesota; Women’s Preventive Cardiology Ce...
متن کاملMolecular mechanisms of statin intolerance
Statins reduce cardiovascular morbidity and mortality in primary and secondary prevention. Despite their efficacy, many persons are unable to tolerate statins due to adverse events such as hepatotoxicity and myalgia/myopathy. In the case of most patients, it seems that mild-to-moderate abnormalities in liver and muscle enzymes are not serious adverse effects and do not outweigh the benefits of ...
متن کاملStatin Intolerance: the Clinician’s Perspective
Muscle problems and other adverse symptoms associated with statin use are frequent reasons for non-adherence and discontinuation of statin therapy, which results in inadequate control of hyperlipidemia and increased cardiovascular risk. However, most patients who experience adverse symptoms during statin use are able to tolerate at least some degree of statin therapy. Given the profound cardiov...
متن کاملThe Impact of Statin Intolerance in Lipid Clinic Patients
Context: Cardiovascular disease is a very common and serious problem in the western world. Statin drug therapy is used in primary, secondary prevention and familial hypercholesterolemia. However, these are frequently associated with adverse effects, causing poor adherence and thus putting patients at risk for future cardiovascular events. Aim: The objective of this study was to review the stati...
متن کاملStatin discontinuation and intolerance: the challenge of lifelong therapy.
Lifelong Therapy Statins are among the most widely prescribed drugs. They reduce atherosclerotic cardiovascular disease events and improve survival in patients with established disease. Recommendations virtually mandate statin use in secondary prevention and widely advocate use for primary prevention. Clinicians initiate statin therapy with the expectation that the patient will continue lifelon...
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ژورنال
عنوان ژورنال: Lipids in Health and Disease
سال: 2007
ISSN: 1476-511X
DOI: 10.1186/1476-511x-6-7